The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.

نویسندگان

  • Francesca L Crowe
  • Timothy J Key
  • Naomi E Allen
  • Paul N Appleby
  • Andrew Roddam
  • Kim Overvad
  • Henning Grønbaek
  • Anne Tjønneland
  • Jutte Halkjaer
  • Laure Dossus
  • Heiner Boeing
  • Janine Kröger
  • Antonia Trichopoulou
  • Vardis Dilis
  • Dimitrios Trichopoulos
  • Marie-Christine Boutron-Ruault
  • Blandine De Lauzon
  • Françoise Clavel-Chapelon
  • Domenico Palli
  • Franco Berrino
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • H Bas Bueno-de-Mesquita
  • Alina Vrieling
  • Carla H van Gils
  • Petra H M Peeters
  • Inger T Gram
  • Guri Skeie
  • Eiliv Lund
  • Laudina Rodríguez
  • Paula Jakszyn
  • Esther Molina-Montes
  • María J Tormo
  • Aurelio Barricarte
  • Nerea Larrañaga
  • Kay-Tee Khaw
  • Sheila Bingham
  • Sabina Rinaldi
  • Nadia Slimani
  • Teresa Norat
  • Valentina Gallo
  • Elio Riboli
  • Rudolf Kaaks
چکیده

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Impact of Combined (Aerobic-resistance) Training on Serum Levels of IGF-I and IGFBP-3 in Men with Prostate Cancer

 Background & Objective:  Prostate cancer is the most common cancer in men. The purpose of this study was to determine the effect of combined training (aerobic-resistance) on serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding proteins 3 (IGFBP-3) in men with prostate cancer.  Materials & Methods:  20 eligible men with prostate cancer with an average age...

متن کامل

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats

ABSTRACT &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objectives: We studied effects of eight weeks of resistance training and IGF-1 injection on serum level of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio in Wistar rats. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods: We randomly divided 28 male Wistar rats into four groups of saline-injected control (C), resista...

متن کامل

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition.

BACKGROUND Some studies suggest that elevated serum insulin-like growth factor (IGF)-I concentrations are associated with an increased risk of prostate cancer and, in particular, with an increased risk of advanced-stage prostate cancer. METHODS We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case...

متن کامل

بررسی سطح سرمی فاکتور رشد شبه انسولین نوع یک (IGF-I) و لپتین در بیماران دیابتی و مقایسه آن با افراد سالم

Background: Diabetes is a common endocrine disease in human kind. In most type II diabetic patients, obesity and overweight status account as the serious health problems worldwide and variety of endocrine factors well known that have regulatory role in weight balance and body composition including Leptin and IGF-I factor. The aim of this study was to examine the correlation between Leptin and I...

متن کامل

بررسی شاخص‌های فاکتور رشد آندوتلیال عروقی، لپتین و فاکتور رشد شبه انسولین در رتینوپاتی نارسی

Background & Aims: Retinopathy of prematurity (ROP) is one of the most causes of retinal detachment and blindness. Although many studies have been conducted on the pathophysiology of ROP, the exact mechanism is yet under investigation. This study aimed at evaluating the role of serum vascular endothelial growth factor (VEGF), insulin like growth factor-I (IGF-I), and its binding protein (IGFBP-...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

دوره 18 5  شماره 

صفحات  -

تاریخ انتشار 2009